Besides, high sTNF-R1 levels are associated with loss of CD4+ T-cells in HIV-ECs with a sustained virological control (Gutierrez-Rivas et al., 2018) and HIV-1 individuals on ART (Richert et al., 2017), and with development of AIDS and non-AIDS events during suppressive ART (Kalayjian et al., 2010; Tenorio et al., 2014). The gene discussed is CD4; the disease is AIDS.