Seventhly, other inflammatory markers, such as IL-1β and cytokines, could play an important role in the pathophysiology of MDD (Dowlati et al., 2010; Chan et al., 2019), future studies should further explore the relationships between these inflammatory markers and gut microbiota to provide novel clues in revealing the pathogenesis of depression. The gene discussed is IL1B; the disease is depressive symptom measurement.