(42) found that EGFR-TKIs can modify the tumor microenvironment (TME) during which the levels of cytotoxic CD8+ T cells and dendritic cells (DCs) were rapidly elevated, Foxp3+ regulatory T cells (Tregs) were eliminated, and M2-like polarization of macrophages was suppressed at an early stage, which were only temporary and disappeared as treatment continued. The gene discussed is EGFR; the disease is neoplasm.