In support of the hypothesis that inflammation is associated with cancer development and progression and also influence the response to treatment, we found that 3 SNPs (rs10519613, rs4819554, and rs4149570) and 5 SNPs (rs10519613, rs4819554, rs2070600, rs755622, and rs4149570) were associated with worse PFS and OS of advanced NSCLC patients treated with EGFR-TKIs, respectively. Here, EGFR is linked to cancer.