Combined with platinum etoposide chemotherapy, it can prevent the recurrence of surgically resected LCNEC (10).Other studies have shown that when the expression of DLL3 in LCNEC patients is negative, the application of platinum containing chemotherapy can improve the survival time of patients, and DLL3 can be used as a sensitive index for monitoring chemotherapy (11). The gene discussed is DLL3; the disease is large cell neuroendocrine carcinoma.