PTEN and breast neoplasm: Proliferation of breast tumors (Figures 5A, B) and distant metastases (Figures 5C, D) were significantly increased in mice treated with PTEN inhibition in vivo and simultaneous inoculation of PTEN-deficient 4T1-luc cells, compared with mice treated with cellular or in vivo PTEN inhibition alone (Figures 5A–D).