PTEN and neoplasm: Inhibition of PTEN at the cellular level in vitro or direct inhibition of PTEN in vivo by intraperitoneal injection of VO-OHpic led to rapid growth of orthotopic transplanted tumors in mice, with general trends towards faster tumor growth and more liver, lung, intestine, bladder, and other distant metastases in line with increasing concentrations of VO-OHpic, including up to almost 100% of lung metastases.