Notably, repotrectinib achieved partial response in NSCLC patients with ROS1 fusion and intracranial metastasis, who were treatment naive or presented solvent-front mutation-mediated resistance to previous ROS1-TKI, demonstrating an efficient intracranial antitumor activity of repotrectinib (97, 99). Here, ROS1 is linked to non-small cell lung carcinoma.