Overall, caution should be taken in applying conclusions based on NF2 populations more broadly to the greater population of sporadic unilateral VS patients—in NF2 patients, the correlation between tumor size and growth with hearing loss is more easily demonstrated; however, in general, these tumors are typically more rapidly growing than sporadic VS, and more histologically aggressive, with NF2-associated tumors more frequently directly involving the cochlear nerve (55, 56). This evidence concerns the gene NF2 and neoplasm.