Moreover, in glioma U87 and A172 cells, the reduction of the expression of related cytokines secreted by glioma cells from the silencing of MD2 strongly confirmed the capability of MD2 on the promotion of polarizing to M2 and N2 phenotypes with respect to macrophages and neutrophils, in which detailed molecular mechanisms and events require future investigations. The gene discussed is LY96; the disease is glioma.