Given that several molecules positively correlated with immune cell infiltration, such as, APOBEC3B and TNFSF13, have been reported as potential biomarkers in gliomas (75, 76), to ensure our findings, we utilized the TIMER, ESTIMATE and CIBERSORT algorithms to further assess the association between MD2 expression and immune cells infiltration. The gene discussed is LY96; the disease is central nervous system cancer.