TP53 and central nervous system cancer: In recent years, with the development of molecular pathology, some molecular markers in glioma have played an important role in the diagnosis and prognosis of the disease, such as isocitrate dehydrogenase (IDH), epidermal growth factor receptor (EGFR), O-6-methylguanine-DNA methyltransferase (MGMT), and tumor protein p53 (TP53) (8).