The ADAM17 expressed on the surface of tumor cells has been reported to bind to the activating receptors (CD16 and NKG2D) of NK cells and rupture them (40); at the same time, it acts as a proteolytic enzyme by participating in the shedding of B7-H6, which is highly expressed in tumor cells (41, 42). This evidence concerns the gene KLRK1 and neoplasm.