Next, we analyzed all TIME elements and the enrichment scores of KCC2 (SLC12A5) and NKCC1 (SLC12A2) in pan-cancer, and found that the expression of KCC2 was significantly correlated with the increase in the number of immune cells, including B cells, Th2 cells, and M1 macrophages (Figure 10A). The gene discussed is SLC12A5; the disease is cancer.