Although there were no statistically significant PFS and OS difference between KCC2 mutation and the WT group (p < 0.05), we found that NKCC1MUT could prominently prolong DFS (p = 0.021), DSS (p = 0.019), and OS (p = 5.74e-04) compared with NKCC1WT cancer patients. Here, SLC12A5 is linked to cancer.