LATS2 and hepatocellular carcinoma: In addition, large tumor suppressor kinase 2 (LATS2) was found to regulate Regorafenib sensitivity in HCC cells, as LATS2 deletion stabilized the Yes-associated protein (YAP) to upregulate antiapoptotic protein Bcl-xL and the multidrug resistance transporter ATP binding cassette subfamily B member 1.