Accumulating evidence has indicated that Sev exerts suppressive effects on the proliferation and metastasis of glioma cells in different molecular mechanisms, including suppressing Rac1/paxillin/FAK and Ras/Akt/mTOR in several tumor cells (21), regulating the ANRIL/let-7b-5p axis (22), and depleting macrophages from the melanoma microenvironment (23). The gene discussed is AKT1; the disease is central nervous system cancer.