In fact, Sev as an inhalational anesthetic has been widely reported its suppressive role in glioma cell proliferation and invasion through regulating different pathways, such as the miR-124-3p/ROCK1 axis (24), miR-146-5p/MMP16 (31), miR-628-5p/MAGT1 axis (27), and PI3K/AKT signaling pathway (32). Here, MMP16 is linked to central nervous system cancer.