By reviewing the literature, LC16A1-AS1 has been reported to enhance radiosensitivity and repress cell proliferation and invasion by regulating the miR-301b-3p/CHD5 axis in hepatocellular carcinoma (11) and to suppress cell proliferation in cervical squamous cell carcinoma by the miR194/SOCS2 axis (12). This evidence concerns the gene SOCS2 and hepatocellular carcinoma.