CD274 and cancer: In the past decade, blocking the PD-1/PD-L1 axis by monoclonal antibodies to overcome the immune suppressive signals in cancer patients and promote the reactivation of antitumor response has been well-established as an efficient treatment in a broad range of cancer types (including but not limited to lung cancer, breast cancer, head and neck cancer, pancreatic cancer, and prostate cancer) (50–54).