Previous studies evaluating durvalumab treatment effect demonstrated a better anti-tumor response in R/M HNSCC patients with high PD-L1 expression versus those with low or no PD-L1 expression (median OS: 7.1 vs 6.0 months, ORR: 16.2% vs 9.2%) (100). The gene discussed is CD274; the disease is head and neck squamous cell carcinoma.