AKT1 and breast carcinoma: Furthermore, Asperolide A can inhibit PI3K/AKT/mTOR activation, leading to inhibited proliferation, inhibited migration, inhibited invasion, enhanced apoptosis, and arrest of G2M/S phase cell cycle in breast cancer cells as same as BEZ235 (inhibitor of PI3K/mTOR), and it hindered the phosphorylation of PI3K, AKT, mTOR, JNK, ERK, but not P65 or P38.