CLPP and obesity due to melanocortin 4 receptor deficiency: Additionally, given that obesity may be associated with OC risk and adverse survival in patients with OC, and there is inter-relationship between mitochondrial dysfunction and obesity as well as the effect of ONC201 on the mitochondrial regulator ClpP, we also studied the anti-tumorigenic effects of ONC201 in both obese and lean mice with OC.