More recent studies found that mitochondrial caseinolytic protease P (ClpP) is another critical target for ONC201, and activation of ClpP by ONC201 results in modulation of the ISR pathway, inhibition of protein synthesis and induction of mitochondrial dysfunction, which eventually leads to inhibition of tumor growth in vitro and in vivo (7, 8). The gene discussed is CLPP; the disease is neoplasm.