In addition, we found that high expression of DRD5 was identified in ovarian tumors of obese mice, and the expression of DRD5 was reduced in the obese and lean mice treated with ONC201 compared with the control mice (Figure 4C, p<0.05), suggesting that ONC201 inhibits ovarian tumor growth through the DRD2/DRD5 pathway. The gene discussed is DRD2; the disease is ovarian neoplasm.