TNFSF10 and neoplasm: Because ONC201 is a selective antagonist of the G protein-coupled receptor DRD2 that causes p53-independent apoptosis through upregulation of TRAIL and DR5 in tumor cells (4), we next detected the effect of ONC201 on DRD2, DRD5 and DR5 in the OVCAR5 and SKOV3 cells.