Because ONC201 is a selective antagonist of the G protein-coupled receptor DRD2 that causes p53-independent apoptosis through upregulation of TRAIL and DR5 in tumor cells (4), we next detected the effect of ONC201 on DRD2, DRD5 and DR5 in the OVCAR5 and SKOV3 cells. Here, TP53 is linked to neoplasm.