MVC-101, is a conditionally active T cell engager that contains two anti-EGFR antibodies, designed for tumor cell- selective targeting (32). Similarly, BCA-101, a chimeric EGFR/TGFβ-targeting antibody is being tested in a Phase 1 trial with pembrolizumab [NCT04429542], which could address not only the immunosuppressive mechanisms (33), but also overcome the resistance to EGFR inhibitors brought on by upregulation of signaling (34, 35). This evidence concerns the gene TGFB1 and neoplasm.