EGFR and neoplasm: MVC-101, is a conditionally active T cell engager that contains two anti-EGFR antibodies, designed for tumor cell- selective targeting (32). Similarly, BCA-101, a chimeric EGFR/TGFβ-targeting antibody is being tested in a Phase 1 trial with pembrolizumab [NCT04429542], which could address not only the immunosuppressive mechanisms (33), but also overcome the resistance to EGFR inhibitors brought on by upregulation of signaling (34, 35).