JAK2 and gastric cancer: demonstrated that in GC cell SGC7901 inactivation of ERK1/2 using PD98059 markedly enhanced JAK2 shRNA-induced cell proliferation inhibition, cell cycle arrest and apoptosis in vitro and in nude mice (ERK1/2 inhibition enhances apoptosis induced by JAK2 silencing in human gastric cancer SGC7901 cells (36).