Wnt/β-catenin signal is vital for stemness properties in cancer, and several studies have suggested that Wnt/β-catenin signal might be an ideal therapeutic target for reversing multidrug resistance in CCA for the observation that enhanced activity of Wnt/β-catenin signal contributes to multi-drug resistance phenotype of CCA through upregulating MDR1 (145). This evidence concerns the gene ABCB1 and cholangiocarcinoma.