ALB and neoplasm: For example, paclitaxel and nanoparticle albumin-bound paclitaxel exhibited similar anti-tumor effect in in vitro experiment; whereas only nanoparticle albumin-bound paclitaxel could inhibit tumor growth in in vivo models, for its ability to reverse CAF-mediated paclitaxel resistance, offering evidence for the advantage of in vivo model in studying the role of TME in drug resistance (60).