Targeting cancer/testis antigens, including New York esophageal squamous cell carcinoma antigen-1 and melanoma-associated antigen (MAGE)-A4, has resulted in responses in patients with advanced synovial sarcoma, melanoma, head and neck cancer, non-small cell lung cancer, and esophagogastric cancer (11–15). This evidence concerns the gene MAGEA4 and non-small cell lung carcinoma.