These findings have been demonstrated in several in vitro studies when small interfering RNAs against NUTM1 or small-molecule BET inhibitors, such as JQ1, have been used to knockdown BRD3/4-NUTM1 and NSD3-NUTM1 patient-derived-tumor cells, leading to cellular differentiation and growth arrest (5, 38, 57, 64, 90). This evidence concerns the gene DNER and neoplasm.