VEGFA and cancer: One of the most important factors for angiogenesis is the VEGF/VEGFR axis.VEGF secreted by cancer cells stimulates the proliferation and survival of endothelial cells leading to change of vascular permeability and neo-angiogenesis (13).VEGF can have a direct effect on multiple immune cells, including T cells, regulatory T cells, dendritic cells, and myeloid derived suppressor cells (14).