Consistent with this, FXYD3 knockdown impairs growth and disperses cells in MCF-7 tumors expressed in mice (23), and in human colon adenocarcinoma Caco-2 cells, FXYD3 knockdown decreases the transepithelial electrical resistance of confluent cell layers consistent with decreased intercellular adhesion (31). The gene discussed is FXYD3; the disease is colon adenocarcinoma.