Interestingly, It was found that the proteins involved in resistance to treatment that has been named the DNA-dependent protein kinase catalytic subunit (PRKDC), which is involved in the repair of double-strand DNA against radiotherapy, can be transported through exosomes, it is assumed that the inhibition of which can play an important role in the treatment of GBM (51). Here, PRKDC is linked to glioblastoma.