Also, it has been demonstrated that exosomes with miR-155 which transferred from monocytes/macrophages to NB cells, and miRNA-21 which has been secreted from NB cells in around of tumor environment have a key role in resistance to chemotherapy, a process that occurs through miR-21/TLR8-NF-κB/exosomal miR-155/TERF1 signaling pathway (64, 65). The gene discussed is TLR8; the disease is neuroblastoma.