We observed a decrease of CD34+ migrated cells following treatment with EVs from both AML cell lines (Figures 7C, D); in particular, KG-1 EVs induced a significant reduction of CD34+ cell migration (p<0.01) and the same trend was observed in ME-1 EV CD34+ treated cells (Figures 7C, D). This evidence concerns the gene CD34 and acute myeloid leukemia.