Furthermore, we can postulate that our results describing the regulation of miR-181a-5p by ADAM8 are not restricted to the role of ADAM8 in GBM, as all other tumor cell lines that we investigated so far such as the triple-negative breast cancer cell line MDA-MB-231 and the PDAC cell line Panc89 show elevated levels of miR-181a-5p upon ADAM8 deficiency (unpublished observations). Here, ADAM8 is linked to glioblastoma.