Not surprisingly, the high expression levels of TEM8 seen in cancerous cells correlate with the susceptibility of particular tumor cells to SVA infection, and the introduction of exogenous TEM8 into otherwise SVA-insensitive tumor cells can significantly increase viral entry and the proportion of cells killed-paving a new way for optimizing TEM8-targeted therapies using oncolytic viruses (5). This evidence concerns the gene ANTXR1 and neoplasm.