EPO and venous thromboembolism: Venous thromboembolic disease can be a potential drawback with high-dose dexamethasone regimens combined with IMiDs, particularly if there are other predisposing factors for venous thromboembolism, such as nephrosis, hypoalbuminemia, or concomitant erythropoietin use; therefore, empirical use of anticoagulation should be considered in those patients at highest risk [14].