NF1 and plexiform neurofibroma: Higher DLQI scores were observed with more extensive skin involvement, female gender, and the presence of plexiform neurofibromas. Upon analysis of DLQI scores, NF1 had no effect in zero cases but had a small, moderate, very large, and extremely large effect in 10 (25%), 11 (27.5%), 10 (25%), and nine (22.5%) patients, respectively.