Other investigators, using human cell lines derived from prostate cancer [68], gliomas [69] as well as T- and B-cell lymphomas [70], all of which expressed detectable levels of ERβ, found that treatment with ERβ specific agonists inhibited cell proliferation in vitro as well as growth and metastatic spread in xenograft in vivo models. This evidence concerns the gene ESR2 and central nervous system cancer.