In normolipidemic individuals, PAF-AH is mainly related to apoB-containing lipoproteins (e.g., as VLDL, LDL, and IDL), with <20% present in HDL, but in hypercholesterolemia PAF-AH activity distribution between LDL and HDL is altered [98]. The gene discussed is APOB; the disease is familial hypercholesterolemia.