FOXO1 and Hyperglycemia: Hepatic FoxO1 works with other up-regulated transcription co-activators, such as cAMP responsive element-binding protein (CREB), to promote increased gene expression of hepatic gluconeogenesis enzymes, such as phosphor-enolpyruvate carboxykinase (PCK), glucose-6-phosphatase (G6Pase), and fructose-1,6-bisphosphatase (FBP), facilitating hepatic gluconeogenesis and the consequences of hyperglycemia and its clinical consequences(Fig. 2) [59].