GLP-1 RAs have the potential to be used or can be used in the treatment of various aging-related diseases, including T2DM, overweight or obesity, hypertension, hyperlipidemia, atherosclerosis, vascular aging, kidney disease, AD, PD, osteoporosis, osteoarthritis and sarcopenia. Here, GCG is linked to obesity due to melanocortin 4 receptor deficiency.