hsa-miR-130b-3p is known to be involved in cancer progression and various inflammatory diseases [29], and no studies have reported on the association between hsa-miR-130b-3p and CH; PTEN is located on 10q23.3 and encodes a lipid phosphatase with important roles in intracellular signal transduction through dephosphorylation of substrates such as Akt and S6 kinase [30]. Here, AKT1 is linked to cyclic hematopoiesis.