A study has shown that the m5C methyltransferase NSUN2 and the recognition protein YBX1 are highly expressed in BLCA tissues, keeping the protooncogene HDGF at stable high expression, hence the poor prognosis of the patients, indicating that m5C methylation mediated by NSUN2 plays a facilitating role in promoting tumor occurrence and progression in BLCA [16]. This evidence concerns the gene YBX1 and bladder transitional cell carcinoma.