Taking all these into consideration, as renal dysfunction only reduces the rule-in but not also the rule out performance of the hs-cTn in MI and higher mortality rates are associated with elevated levels of hs-cTnI, this biomarker continues to play the central role in the ACS diagnosis algorithm even for patients with CKD [55], but future research is still open in better understanding its optimal interpretation in this setting. Here, TNNI3 is linked to chronic kidney disease.