Even though three observational studies that evaluated the diagnostic performance of hs-cTn by comparing the performance of the 0/1-hour ESC algorithms of rapid rule-in and rule-out in patients with and without renal dysfunction using both hs-TnT and hs-TnI showed lower specificity in CKD patients, the sensitivity of the test remained close to 100%, hs-cTnI being able to identify over 90% of MI within 3 hours [46]. Here, TNNI3 is linked to chronic kidney disease.