The ABC-stroke score (age, biomarkers, and clinical history) included the cardiac biomarkers N-terminal fragment B-type natriuretic peptide (NT-proBNP) and hs-cTn and was reported to predict stroke or systemic embolism with a significantly higher accuracy than the currently used CHA2-DS2 -VASc score. The gene discussed is NPPB; the disease is stroke disorder.