Using exosomal mRNA sequencing data, we compared the expression genes that were essential for diagnosis and prognostication of DLBCL, PMBL, FL, MCL, and ENKTL, including MYC, BCL2, BCL6, CCND1, and genes belonging to the lymph2CX assay that are used commonly as a gene signature discriminating the cell of origin in DLBCL 27-29. This evidence concerns the gene FLT3LG and diffuse large B-cell lymphoma.