Additionally, the information related with exosomal mRNAs expression could be useful for predicting the prognosis of patients because the previous study reported the poor prognosis of B-cell lymphoma patients with exosomal BCL-6 and C-MYC mRNA at diagnosis and the association of exosomal AKT mRNA with the lack of response to rituximab-based treatment 37. Here, AKT1 is linked to B-cell non-Hodgkin lymphoma.