Intriguingly, EXOSC5 were overexpressed in leukemic blasts from patients suffering from acute myelogenous leukemia and chronic myelogenous leukemia (CML) blast crisis but barely detectable in normal bone marrow, peripheral blood or leukemic cells from patients with stable-stage CML 19. This evidence concerns the gene EXOSC5 and chronic myelogenous leukemia, BCR-ABL1 positive.