Using standard RT-PCR expression analysis, Scanlan et al. 23 observed that the BRDT gene was aberrantly activated in 12 of 47 cases of non-small cell lung cancers, 1 of 12 cases of squamous cell carcinoma of the head and neck, and 1 of 12 cases of esophageal squamous cell carcinoma. The gene discussed is BRDT; the disease is esophageal squamous cell carcinoma.