It has been shown that hypoxia can regulate the expression of Rab7 and Rab27a by inducing the expression of STAT3, thereby promoting the release of ovarian cancer cell exosomes 63; HIF can activate the transcription genes of Rab22a and small GTPase Rab22a expression mediates the release of breast cancer cell exosomes 64. This evidence concerns the gene RAB22A and ovarian carcinoma.