The risk score was calculated as follows: score = 0.238 * expression level of ABCC5+ 0.144 * expression level of BCL10 + 0.022 * expression level of FDPS + 0.137 * expression level of ITGB1BP1 + 0.026 * expression level of MSH2 + 0.011 * expression level of PABPC1 + 0.185 * expression level of PRDX1 + 0.031 * expression level of SLC25A19 +0.016 * expression level of YWHAH. The median risk score of the TCGA cohort served as the unified cut-off for dividing HCC patients into high- and low-risk groups (Figure 3A). This evidence concerns the gene MSH2 and hepatocellular carcinoma.