As shown in Figure 9, significant functions associated with tumorigenesis were enriched in the high-risk group defined by the 9-gene signature with the FDR<0.05, including Cell cycle G1-S phase transition, Regulation of autophagy, Apoptotic mitochondrial changes, Focal adhesion, Cell cycle pathway, Erbb signaling pathway, Notch signaling pathway, P53 signaling pathway, Wnt signaling pathway and Pathways in cancer. The gene discussed is TP53; the disease is cancer.