ZC3H12A and esophageal adenocarcinoma: Recently, miR-421 was found to be dysregulated in breast and colon tumors 47, 48.It has been reported that miR-421 promotes the development of osteosarcoma by regulating the target gene MCPIP1 and that it might serve as a valuable biomarker in patients with esophageal adenocarcinoma and osteosarcoma 49-51.