We found that APOE was more highly expressed in breast cancer, Esophageal carcinoma, head and neck squamous cell carcinoma, liver hepatocellular carcinoma, prostate adenocarcinoma, stomach adenocarcinoma, thyroid carcinoma and uterine corpus endometrial carcinoma than the corresponding adjacent tissues. The gene discussed is APOE; the disease is carcinoma of esophagus.