Besides, research by Gao et al, found that the interference of PYCR1 increased the expression of Bcl-2 and c-Myc, and the phosphorylation level of JAK2 and STAT3 in lung adenocarcinoma, which further affected the JAK/STAT signaling pathway 27,30,31. The gene discussed is BCL2; the disease is lung adenocarcinoma.