Regarding the report on the downstream related target genes of miR-34a and their signaling pathways, a luciferase reporter gene, RT-qPCR and western blotting experiments confirmed that miR-34a can target the HK1 molecule and reduce the expression level of HK1, promoting the vitality and proliferation of hepatocellular carcinoma cells20. Here, HK1 is linked to hepatocellular carcinoma.