The result showed that the down-regulation of serum exosomal miR-34a was significantly related to the degree of differentiation, TNM stage, tumor invasion depth, lymph node metastasis and vascular invasion (P<0.05), while there was no statistical difference in patient gender, age, ALT, AST, viral infection, cirrhosis and tumor size (P>0.05) (Table 1). This evidence concerns the gene GPT and Cirrhosis.