TP53 and neoplasm: However, GSEA showed that in the RAD21 low expression group, the DEGs were mainly enriched in genes associated with aggressive tumor processes, such as angiogenesis, E2F targets, EMT, G2/M checkpoint, and Kirsten rat sarcoma viral oncogene (KRAS) signaling of the myelocytomatosis (MYC) viral proto-oncogene targets version 1 and P53 pathway (Figure 8D).