To investigate whether the tumor suppressor role of BRD7 is dependent on p53 and its bromodomain, we transfected the vectors expressing wild-type BRD7 alone, or the vectors expressing BRD7∆brd alone, or co-transfected the wild-type BRD7 vector and p53 siRNA pools into MCF-7 cells. Here, TP53 is linked to neoplasm.