Similarly, 65.0% of the 20 highest expressed AMD-related risk genes were comparably expressed between human and mice, among them APOE, TGFBR1, HERPUD1 (Homocysteine Inducible ER Protein With Ubiquitin Like Domain 1), SCPEP1 (Serine Carboxypeptidase 1) and EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A) (Figure 3F). This evidence concerns the gene APOE and age-related macular degeneration.