We found that in the early stage of virus infection, the infection efficiency of B.1.1.7, B.1.351, and B.1.617.2 in Caco2-hACE2, 293T-hACE2, and 293T-hACE2-TMPRSS2 cells was higher than that of the reference D614G strain. The gene discussed is TMPRSS2; the disease is viral infectious disease.