CD8A and autoimmune lymphoproliferative syndrome: Patients with ALPS usually have an increased proportion of T-cells expressing the alpha/beta T-cell receptor but lacking both CD4 and CD8 (α/β-double negative T- cells, aka DNTCs), increase in HLA-DR positive cells (on α/β DNTCs and CD8+ T-cells) with a concomitant loss/absence in CD25+ T-cells and reduced percentage of CD27+ B cells (2).